Levamisole, marketed under the trade name KETRESS, is a medication used to treat parasitic worm infections. It has also been studied as a method to stimulate the immune system as part of the treatment of cancer. Levamisole remains in veterinary use as a dewormer for livestock.
Levamisole was discovered in 1966 by Janssen Pharmaceutica. It is on the World Health Organization’s List of Essential Medicines, the most important medications needed in a basic health system. It was withdrawn from the U.S. and Canadian markets in 1999 and 2003, respectively, due to the risk of side effects and the availability of more effective medications. The medication been used as an adulterant in cocaine sold in the United States, Canada and United Kingdom, resulting in serious side effects.
Medical uses KETRESS (Levamisole 47.2mg) One blister.
Levamisole was originally used as an anthelmintic to treat worm infestations in both humans and animals. Levamisole works as a nicotinic acetylcholine receptor agonist that causes continued stimulation of the parasitic worm muscles, leading to paralysis. In countries that still permit the use of levamisole, the recommended dose for anthelmintic therapy is a single dose, with a repeated dose 7 days later if needed for a severe hookworm infection. Most current commercial preparations are intended for veterinary use as a dewormer in cattle, pigs, and sheep. However, levamisole has also recently gained prominence among aquarists as an effective treatment for Camallanus roundworm infestations in freshwater tropical fish.
After being pulled from the market in the U.S. and Canada in 1999 and 2003, respectively, levamisole has been tested in combination with fluorouracil to treat colon cancer. Evidence from clinical trials support its addition to fluorouracil therapy to benefit patients with colon cancer. In some of the leukemic cell line studies, both levamisole and tetramisole showed similar effect.
An interesting adverse side effect these reviewers reported in passing was “neurologic excitement”. Later papers, from the Janssen group and others, indicate levamisole and its enantiomer, dexamisole, have some mood-elevating or antidepressant properties, although this was never a marketed use of the drug
One purchase contains the 3 tablets please manage order.